Salamanca M, Zambrano C, Mejia J, Motta A, Jiménez P, Restrepo S, Celis A. (2021)
Seborrheic dermatitis and its relationship with Malassezia spp
Infectio (ISSN 0123-9392)
Article
Adriana Marcela Celis Ramirez
Adriana Marcela Celis Ramirez
PhD Science
acelis @uniandes.edu.co
Profesor Asistente
Departamento de Ciencias Biológicas
Profile
Recent Courses
- 2020
SEMIN.INVESTIGACIÓN DOC. L.D.1
First period
Doctoral Level
BACTERIOLOGÍA CLÍNICA-TEO
First period
Bachelor Level
Recent Products
Celis A.
ESTUDIO DE LA INTERACCIÓN – PATÓGENO- HOSPEDERO: UNA APROXIMACIÓN MEDIANTE LA INFECCIÓN DE QUERATINOCITOS POR M. globosa
Banco de la República.
Proposal
Recent Degrees
PhD Science
Doctoral degree
Universiteit Utrecht
2017
Holanda
Magíster En Ciencias Biológicas. Área: Microbiología
Master degree
Universidad De Los Andes
2003
Colombia
Recent Projects
- 2019
- Characterization of lipid droplets in Malassezia spp: unraveling the role in the lipid metabolism
Duration: 36 months
PR.3.2018.5507
Interest in the study of lipid droplets in other organisms than humans is increasing. Our previous results revealed that LDs are present and can be detected in Malassezia spp. However, LD structure and dynamics seem very different from LDs detected in human cells, even their morphology is very different. The lipid dependence in Malassezia genus makes this organelle very attractive to study and to characterize. We aim to understand the physiological relevance of LDs and the dynamic behavior of LDs in lipid homeostasis and metabolism. In addition, their contribution to cellular membrane and organelle integrity, stress response, prevention of lipotoxicity, growth and survival will be investigated. The main goal of this proposal is to characterize LDs from Malassezia spp by in silico genomic analysis, in combination with lipidomics and proteomics. Additionally, we will evaluate LD morphology and dynamics using live-cell imaging (confocal microscopy) and detailing the ultrastructure with transmission electron microscopy (TEM). The detection of the surface proteins in LDs will be performed by tagging perilipin protein using Agrobacterium-mediated genetic transformation system by a binary T-DNA vector with the green fluorescent protein gene (gfp). This research will allow us to investigate LD from Malassezia spp. at the cellular and molecular level, which may become highly relevant to understand and make assessments to the physiological regulation of global lipid metabolism in this yeast. Additionally, lipidomic and proteomic data integration will be carried out in order to contextualize lipid metabolism based on LD using a previously reported metabolic model. This contextualization will allow us to understand the underpinnings behind metabolic flow distribution in the dynamic of LD lipid content to have a better understanding of the regulatory systems, underlying lipid functions and interactions in the context of cellular and physiology aspects in the yeast.
Courses
- 2020
SEMIN.INVESTIGACIÓN DOC. L.D.1
First period
Doctoral Level
BACTERIOLOGÍA CLÍNICA-TEO
First period
Bachelor Level
MICROBIOLOGÍA MÉDICA-TEO
First period
Bachelor Level
SEMINARIOS INVESTIGACIÓN L.D.
Second period
Master Level
SEMINARIOS INVESTIGACIÓN L.D.
First period
Master Level
SEMIN.INVESTIGACIÓN DOC. L.D.1
Second period
Doctoral Level
MICROBIOLOGÍA MÉDICA-TEO
Second period
Bachelor Level
BIOLOGÍA DE MICROORGANISMOS
First period
Bachelor Level
INFEC.FUNGI:SUPER A PROFUN-TEO
Second period
Bachelor Level
SEMIN.INVESTIGACIÓN DOC. L.D.2
Second period
Doctoral Level
BIOLOGÍA DE MICROORGANISMOS
Second period
Bachelor Level
- 2019
- 2018
- 2017
- 2016
- 2015
- 2014
- 2013
- 2012
- 2011
Products
Salamanca M, Zambrano C, Mejia J, Motta A, Jiménez P, Restrepo S, Celis A. (2021)
Seborrheic dermatitis and its relationship with Malassezia spp
Infectio (ISSN 0123-9392)
Article
Celis A.
ESTUDIO DE LA INTERACCIÓN – PATÓGENO- HOSPEDERO: UNA APROXIMACIÓN MEDIANTE LA INFECCIÓN DE QUERATINOCITOS POR M. globosa
Banco de la República.
Proposal
Saenz V, Alvarez-Moreno C, Le Pape P, Restrepo S, Guarro J, Celis A. (2020)
A One Health Perspective to Recognize Fusarium as Important in Clinical Practice
Journal of Fungi (ISSN 2309-608X)
Article
Celis A, Amezquita A, Cardona J, Matiz L, Andrade J, Triana S, Mantilla M, Restrepo S, Gonzalez A, Hans de Cock. (2020)
Analysis of Malassezia lipidome disclosed differences among the species and reveals presence of unusual yeast lipids
Frontiers in Cellular and Infection Microbiology (ISSN 2235-2988)
Article
Mantilla M, Ariza G, Cabrera C, Helms B, Restrepo S, Celis A. (2020)
Caracterización de lo desconocido: un acercamiento a la estructura y composición de los Lipid Doplets de Malassezia pachydermatis CBS 1879.
Infectio (ISSN 0123-9392)
Article
Fonseca A .Caracterización epidemiológica, molecular y evaluación del perfil de sensibilidad en aislamientos clínicos de Staphylococcus aureus procedentes de la ciudad de Bogotá D.C.. (2020).
Caracterización epidemiológica, molecular y evaluación del perfil de sensibilidad en aislamientos clínicos de Staphylococcus aureus procedentes de la ciudad de Bogotá D.C.
Thesis
Mantilla M, Cabrera C, Ariza G, Hans de Cock, Helms B, Restrepo S, Celis A.
Characterizing the unknown: an approach to the structure and composition of lipid droplets in Malassezia pachydermatis CBS 1879
Event
Mijnhardt S, Celis A, Hans de Cock.
Development of skin model systems to study lipid-dependent growth of Malassezia spp.
Event
Rios A, Gonzalez M, Carazzone C, Celis A. (2020)
Diferencias invisibles entre hermanas. Determinación de compuestos orgánicos volátiles (COVs) producidos por Malassezia globosa‚ Malassezia restricta y Malassezia sympodialis.
Infectio (ISSN 0123-9392)
Article
Cabrera C, Mantilla M, Mónica P. Cala, Jimenez E, Celis A.
Disclosing M. globosa lipid metabolism through lipid droplets and secretome analysis
Event
Soto D, Uribe L, Torres M, Garavito Z, Celis A. (2020)
Embriones de pez cebra (Danio rerio): en la busqueda de nuevos modelos de infección alternativos para Malassezia furfur CBS 1878
Infectio (ISSN 0123-9392)
Article
Rey F .Estandarización de Galleria mellonella como modelo de infección de Malassezia pachydermatis CBS 1879. (2020).
Estandarización de Galleria mellonella como modelo de infección de Malassezia pachydermatis CBS 1879
Thesis
Ehemann K, Sastoque A, Guevara M, Celis A. (2020)
Evaluación de inhibidores candidatos del crecimiento de Malassezia
Infectio (ISSN 0123-9392)
Article
Carreño F, Heydys Martinez, Martinez N, Torres M, Celis A, Briceño J, Gaitan J. (2020)
Evaluación del efecto in vitro de una emulsión de Perfluorooctilbromuro en el crecimiento de Pseudomonas aeruginosa.
Infectio (ISSN 0123-9392)
Article
Ehemann K, Sastoque A, Guevara M, Restrepo S, Hans de Cock, Gonzalez A, Celis A.
Evaluation of new candidates for Malassezia spp. growth inhibition
Event
Torres M, Pinzon E, Rey F, Heydys Martinez, Parra C, Celis A. (2020)
Galleria mellonella as a Novelty in vivo Model of Host-Pathogen Interaction for Malassezia furfur CBS 1878 and Malassezia pachydermatis CBS 1879
Frontiers in Cellular and Infection Microbiology (ISSN 2235-2988)
Article
Gutierrez Y .Identificación de especies de Neocosmospora asociadas a micosis humanas usando MALDI-TOF.. (2020).
Identificación de especies de Neocosmospora asociadas a micosis humanas usando MALDI-TOF.
Thesis
Torres M, Hans de Cock, Celis A. (2020)
In Vitro or In Vivo Models, the Next Frontier for Unraveling Interactions between Malassezia spp. And Hosts. How Much DoWe Know?
Journal of Fungi (ISSN 2309-608X)
Article
Puentes C, Mantilla M, Guevara M, Celis A. (2020)
Investigando lo atípico: identificación y perfiles de sensibilidad de aislamientos de Malassezia spp.
Infectio (ISSN 0123-9392)
Article
Rios A, Gonzalez M, Carazzone C, Celis A.
Malassezia flavors: volatile organic compounds (VOCs) produced by Malassezia globosa, Malassezia restricta and Malassezia sympodialis
Event
Mantilla M .Malassezia pachydermatis CBS 1879 LIPID DROPLETS (LD): AN APPROACH FOR THE CHARACTERIZATION OF THE STRUCTURE AND COMPOSITION. (2020).
Malassezia pachydermatis CBS 1879 LIPID DROPLETS (LD): AN APPROACH FOR THE CHARACTERIZATION OF THE STRUCTURE AND COMPOSITION
Thesis
Puentes C .Malassezia spp., identificación y perfiles de sensibilidad. (2020).
Malassezia spp., identificación y perfiles de sensibilidad
Thesis
Sastoque A, Triana S, Ehemann K, Suarez L, Restrepo S, Fernandez M, Gonzalez A, Celis A. (2020)
New Therapeutic Candidates for the Treatment of Malassezia pachydermatis -Associated Infections
SCIENTIFIC REPORTS (ISSN 2045-2322)
Article
Castillo A, Cañas S, Guevara M, Guarro J, Restrepo S, Celis A. (2020)
Transcriptional response of Fusarium oxysporum and Neocosmospora solani challenged with amphotericin B or posaconazole
Microbiology (ISSN 1350-0872)
Article
Torres M, Soto D, Uribe L, Garavito Z, Celis A.
Zebrafish (Danio rerio) embryos: in search for new alternative infection models for Malassezia furfur CBS 1878
Event
Celis A.
Understanding Malassezia lipid metabolism How may lipid dependence affect host-pathogen interaction?
Research International Proposal
Ariza G .Caracterización morfológica de Lipid droplets en Malassezia spp. mediante microscopía confocal de barrido láser.. (2019).
Caracterización morfológica de Lipid droplets en Malassezia spp. mediante microscopía confocal de barrido láser.
Thesis
Gonzalez M, Guevara M, Celis A, Molina J, Palacios-Rodríguez P, Hernandez J, Gonzalez M, Brunetti A, Amezquita A, Carazzone C. (2019)
DE LO DESCRIPTIVO A LO EXPLICATIVO: USO DE HS-SPME/GC-MS PARA ESTUDIAR LA COMUNICACIÓN QUÍMICA EN MICROORGANISMOS Y VERTEBRADOS
XVIII CONGRESO COLOMBIANO DE QUÍMICA
Inproceeding
Soto D .Estandarización de un protocolo de infección de Malassezia furfur para la evaluación de tropismo en larvas de pez cebra (Danio rerio). (2019).
Estandarización de un protocolo de infección de Malassezia furfur para la evaluación de tropismo en larvas de pez cebra (Danio rerio)
Thesis
Ehemann K .Evaluación de inhibidores candidatos del crecimiento de Malassezia. (2019).
Evaluación de inhibidores candidatos del crecimiento de Malassezia
Thesis
Gonzalez L .Evaluación de la actividad inhibidora de los péptidos antimicrobianos Buforina II y Frenatin 2.3S ante Malassezia spp.. (2019).
Evaluación de la actividad inhibidora de los péptidos antimicrobianos Buforina II y Frenatin 2.3S ante Malassezia spp.
Thesis
Sastoque A, Ehemann K, Triana S, Fernandez M, Gonzalez A, Restrepo S, Celis A. (2019)
Evaluation of new therapeutic candidates for the treatment of Malassezia pachydermatis
9th Trends in Medical Mycology Held
Inproceeding
Garzon L, Rueda L, Celis A, Cardenas M, Guevara M. (2019)
Exophiala psychrophila: A new agent of chromoblastomycosis
Medical Mycology Case Reports (ISSN 2211-7539)
Article
Celis A, Parra C, Pinzon E. (2019)
Galleria mellonella as a novelty model to study host – pathogen interaction in Malassezia furfur CBS 1878
9th Trends in Medical Mycology Held
Inproceeding
Celis A, Guevara M, Galvis-Marin J, Rodriguez M, Castaneda-Salazar R, Linares-Linares M, Triana S, Pulido A. (2019)
Genotyping of Malassezia pachydermatis disclosed genetic variation in isolates from dogs in Colombia
Pesquisa Veterinaria Brasileira (ISSN 0100-736X)
Article
Gonzalez M, Guevara M, Celis A, Carazzone C. (2019)
Humans Smell to their Skin Microbiome and Microbes Smell Like What They Eat
67TH ASMS Conference on Mass Spectrometry and Allied Topics
Inproceeding
Gonzalez M, Carazzone C, Celis A, Molina J.
Humans Smell to their Skin Microbiome and Microbes Smell Like What They Eat. 67TH ASMS Conference on Mass Spectrometry and Allied Topics June 2 - 6, 2019, Atlanta, Georgia. Poster
Event
Mantilla M, Ariza G, Cabrera C, Restrepo S, Celis A. (2019)
Studying the unknown: implementation of two recognized protocols to characterize lipid droplets in Malassezia pachydermatis
9th Trends in Medical Mycology Held
Inproceeding
Celis A.
Understanding Malassezia lipid metabolism
Research International Proposal
Gonzalez M, Celis A .YEAST SMELL LIKE WHAT THEY EAT: ANALYSIS OF VOLATILE ORGANIC COMPOUNDS OF Malassezia furfur IN GROWTH MEDIA SUPPLEMENTED WITH DIFFERENT LIPIDS. (2019).
YEAST SMELL LIKE WHAT THEY EAT: ANALYSIS OF VOLATILE ORGANIC COMPOUNDS OF Malassezia furfur IN GROWTH MEDIA SUPPLEMENTED WITH DIFFERENT LIPIDS
Thesis
Gonzalez M, Celis A, Guevara M, Molina J, Carazzone C. (2019)
Yeast Smell Like What They Eat: Analysis of Volatile Organic Compounds of Malassezia furfur in Growth Media Supplemented with Different Lipids
Molecules (ISSN 1420-3049)
Article
Celis A, Cardona J, Restrepo S, Gonzalez A, Wosten H, Hans de Cock. (2018)
Lipidómica: una nueva estrategia para resolver especies crípticas en el complejo Malassezia furfur
Infectio (ISSN 0123-9392)
Article
Celis A.
Unraveling the lipid-dependent pathophysiology of Malassezia yeast: an approach to keratinocyte infection by M. globosa
Research International Proposal
Bello N, Pastrana H, Garavito M.F, Avila A, Celis A, Restrepo S, Muñoz A, Hurtado J. (2018)
Antibacterial Activities of Azole Complexes Combined with Silver Nanoparticles
Molecules (ISSN 1420-3049)
Article
Hans de Cock, Celis A, Triana S, Wosten H. (2018)
Characterization of growth of lipid-dependent Malassezia yeast species, members of the skin mycobiome
Medical Mycology (ISSN 1369-3786)
Article
Celis A, Hans de Cock, Triana S, Cardona L, Restrepo S, Gonzalez A, Wosten H. (2018)
Identification and characterization of lipid droplets in Malassezia furfur
Medical Mycology (ISSN 1369-3786)
Article
Celis A, Rua A. (2018)
Infección por Malassezia spp.
Fundamentos de las micosis humanas (ISBN 978-958-8843-98-8)
Inbook
Navarro P, Guevara M, Paredes K, Celis A, Guarro J, Capilla J. (2018)
Lack of correlation of ECV and outcome in an in vivo murine model of systemic fusariosis
Diagnostic Microbiology and Infectious Disease (ISSN 0732-8893)
Article
Celis A, Hans de Cock, Triana S, Cardona J, Restrepo S, Gonzalez A, Wosten H.
Lipidomic analyses of Malassezia reveals the presence of branched fatty acid esters of hydroxy fatty acids (FAHFAs)
Event
Hans de Cock, Valdes I, Rosa M, Morren M, Boerefijn S, Kraak B, Dijksterhuis J, Celis A, Triana S, Wosten H, Haagsman H, Van H.
New developments for therapeutic treatment of skin infections caused by Malassezia spp.
Event
Guevara M, Cañas S, Restrepo S, Guarro J, Celis A. (2018)
Revelando mecanismos de resistencia a compuesto antifúngicos en "Fusarium-like"
Infectio (ISSN 0123-9392)
Article
Guevara M, Guarro J, Restrepo S, Celis A. (2018)
Two new species within Fusarium solani complex isolated from human nails in Colombia.
Medical Mycology (ISSN 1369-3786)
Article
Celis A, Vos P, Triana S, Medina C, Escobar N, Restrepo S, Wosten H, Hans de Cock. (2017)
Highly efficient transformation system for Malassezia furfur and Malassezia pachydermatis using Agrobacterium tumefaciens-mediated transformation
Journal of Microbiological Methods (ISSN 0167-7012)
Article
Galvis-Marin J, Rodriguez M, Pulido A, Castaneda-Salazar R, Celis A, Linares-Linares M. (2017)
In vitro antifungal activity of azoles and amphotericin B against Malassezia furfur by the CLSI M27-A3 microdilution and Etest®methods
Revista Iberoamericana de Micologia (ISSN 1130-1406)
Article
Olave M, Vargas-zambrano J, Celis A, Castaneda E, Gonzalez J. (2017)
Infective capacity of Cryptococcus neoformans and Cryptococcus gattii in a human astrocytoma cell line - Mycoses 2017 (artículo completo) DOI: 10.1111/myc.12619
Mycoses (ISSN 0933-7407)
Article
Triana S, Hans de Cock, Ohm R, Danies G, Wosten H, Restrepo S, Gonzalez A, Celis A. (2017)
Lipid metabolic versatility in Malassezia spp. yeasts studied through metabolic modeling
Frontiers in Microbiology (ISSN 1664-302X)
Article
Celis A, Wosten H, Triana S, Restrepo S, Hans de Cock. (2017)
Malassezia spp. beyond The Mycobiota
SM Dermatology Journal (ISSN 2575-7792)
Article
Rodriguez N .Purificación de la Enzima Homoserina Deshidrogenasa de Malassezia furfur y Detección de Treonina como Inhibidor Competitivo a partir de la Actividad enzimática y los Parámetros Cinéticos de la enzima. (2017).
Purificación de la Enzima Homoserina Deshidrogenasa de Malassezia furfur y Detección de Treonina como Inhibidor Competitivo a partir de la Actividad enzimática y los Parámetros Cinéticos de la enzima
Thesis
Guevara M, Cano-Lira J, M. C. Cepero de García, Sopo L, De Bedout C, Cano L, Garcia A, Motta A, Amezquita A, Cardenas M, Espinel-Ingroff A, Guarro J, Restrepo S, Celis A. (2016)
Genotyping of Fusarium Isolates from Onychomycoses in Colombia: Detection of Two New Species Within the Fusarium solani Species Complex and In Vitro Antifungal Susceptibility Testing
Mycopathologia (ISSN 0301-486X)
Article
Castillo K, Bello N, Nuñez-Dallos N, Pastrana H, Celis A, Restrepo S, Hurtado J, Avila A. (2016)
Metal complex derivatives of azole: A study on their synthesis, characterization, and antibacterial and antifungal activities
Journal of the Brazilian Chemical Society (ISSN 0103-5053)
Article
Triana S, Gonzalez A, Hans de Cock, Restrepo S, Celis A. (2016)
New therapeutic targets in two species of Malassezia spp discovered by In silico enzyme deletion in their metabolic reconstruction
6th Conference on Physiology of Yeasts and Filamentous Fungi July 11-14, 2016, Lisbon, Portugal
Inproceeding
Triana S .New therapeutic targets in two species of Malassezia spp discovered by In silico enzyme deletion in their metabolic reconstruction.. (2016).
New therapeutic targets in two species of Malassezia spp discovered by In silico enzyme deletion in their metabolic reconstruction.
Thesis
Celis A, Amado Y, Urbina D, Hans de Cock, Restrepo S.
Analysis of gene expression profiles in M. Furfur using next generetion
Event
Triana S, Gonzalez A, Ohm R, Wosten H, Hans de Cock, Restrepo S, Celis A. (2015)
Draft genome sequence of the animal and human pathogen Malassezia pachydermatis strain CBS 1879
Genome Announcements (ISSN 2169-8287)
Article
Castillo K .EVALUATION OF in vitro ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF METAL BASED AZOLES AND SILVER NANOPARTICLES. (2015).
EVALUATION OF in vitro ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF METAL BASED AZOLES AND SILVER NANOPARTICLES
Thesis
Castillo K, Bello N, Hurtado J, Avila A, Pastrana H, Restrepo S, Celis A.
Evaluación in vitro de la actividad antifúngica y antibacteriana de nuevos derivados azólicos con metales de transición
Event
Triana S, Gonzalez A, Restrepo S, Celis A.
First metabolic network of the seborrheic dermatitis related yeast Malassezia furfur. 6 Congress of European Microbiologists. 7-11 June 2015 Maastricht, The Netherlands
Event
Triana S, Gonzalez J, Hans de Cock, Gonzalez A, Restrepo S, Celis A.
Metabolic networks of five Malassezia species
Event
Triana S .Metabolic reconstruction of five Malassezia genomes. (2015).
Metabolic reconstruction of five Malassezia genomes
Thesis
Triana S, Gonzalez J, Gonzalez A, Restrepo S, Celis A. (2015)
Metabolic reconstruction of five Malassezia genomes. III Congreso Colombiano de Biología Computacional y Bioinformatica. Medellín 16-18 de septiembre 2015
Other Publication
Triana S, Gonzalez J, Restrepo S, Hans de Cock, Celis A, Gonzalez A.
Searching Therapeutic Candidates Against the Yeast Malassezia Sp. By a Metabolic Reconstruction, Feasibility Analysis and Proteomics Validation
Event
Castillo A, Castro J, Restrepo S, Celis A.
TRANSCRIPTIONAL PROFILE OF FUSARIUM OXYSPORUM AND FUSARIM SOLANI CHALLENGED WITH ANTIFUNGAL COMPOUNDS IN VITRO
Event
Castillo A .Transcriptomic analyses of Fusarium oxysporum and Fusarium solani challenged with antifungal compounds both in vitro and in vivo. (2015).
Transcriptomic analyses of Fusarium oxysporum and Fusarium solani challenged with antifungal compounds both in vitro and in vivo
Thesis
Castillo A, Restrepo S, Cardenas M, Celis A. (2014)
Análisis del perfil transcripcional de Fusarium oxysporum y F. solani frente a compuestos antifúngicos in vitro
ACTUALIDADES BIOLOGICAS (ISSN 0304-3584)
Article
Triana S .Caracterización enzimática preliminar y purificación parcial de una lipasa extracelular relacionada con la actividad lipolitica de Malassezia furfur con asimilación atípica de Tween 80. (2014).
Caracterización enzimática preliminar y purificación parcial de una lipasa extracelular relacionada con la actividad lipolitica de Malassezia furfur con asimilación atípica de Tween 80
Thesis
Triana S, Celis A, Gonzalez A, Restrepo S. (2014)
Caracterización enzimática preliminar y purificación parcial de una lipasa extracelular relacionada con la actividad lipolítica de Malassezia furfur con asimilación atípica de Tween 80
ACTUALIDADES BIOLOGICAS (ISSN 0304-3584)
Article
Castillo K, Restrepo S, Celis A, Hurtado J, Avila A.
Evaluación de la actividad antifúngica in vitro de derivados triazólicos con metales de transición y nanopartículas de plata
Event
Molina A .Evaluación de la colonización de aislamientos de Malassezia furfur Cepa CBS 1878 y Malassezia furfur con asimilación atípica de Tween 80 Cepa 4DS, causantes de dermatitis atópica en modelo murino. (2014).
Evaluación de la colonización de aislamientos de Malassezia furfur Cepa CBS 1878 y Malassezia furfur con asimilación atípica de Tween 80 Cepa 4DS, causantes de dermatitis atópica en modelo murino
Thesis
Olave M, Vargas-zambrano J, Celis A, Castañeda C, Gonzalez J. (2014)
Infective capacity of Cryptococcus neoformans and C. gattii in a human astrocytoma cell line
Mycoses (ISSN 0933-7407)
Article
Gomez D .Insights into Malassezia fufur phenotypic variation through the differential expression of Mgl_3612 allergen. (2014).
Insights into Malassezia fufur phenotypic variation through the differential expression of Mgl_3612 allergen
Thesis
Celis A, Restrepo S. (2014)
Revisión de los estudios realizados en el género Malassezia, en Colombia
ACTUALIDADES BIOLOGICAS (ISSN 0304-3584)
Article
Guevara M .Characterization and in vitro antifungal susceptibility profiles of Fusarium spp. clinical isolates.. (2013).
Characterization and in vitro antifungal susceptibility profiles of Fusarium spp. clinical isolates.
Thesis
Salamanca M .EFECTIVIDAD DEL TRATAMIENTO ANTIFUNGICO EN DERMATITIS SEBORREICA: UNA REVISION DE TEMA. (2013).
EFECTIVIDAD DEL TRATAMIENTO ANTIFUNGICO EN DERMATITIS SEBORREICA: UNA REVISION DE TEMA
Thesis
Guevara M, Restrepo S, Celis A. (2013)
Los hongos como patógenos en humanos
Hipótesis: Apuntes Científicos Uniandinos (ISSN 1692-729X)
Article
Mejia J .Neoscytalidium dimidiatum como agente causal de micosis. (2013).
Neoscytalidium dimidiatum como agente causal de micosis
Thesis
Amado Y, Patiño A, M. C. Cepero de García, Tabima J, Motta A, Cardenas M, Bernal A, Restrepo S, Celis A. (2013)
Seborrheic dermatitis: predisposing factors and ITS2 secondary structure for Malassezia phylogenic analysis
Medical Mycology (ISSN 1369-3786)
Article
Rodriguez N .ANÁLISIS DEL PERFIL DE EXPRESIÓN GÉNICA DE Fusarium spp. FRENTE A COMPUESTOS ANTIFÚNGICOS MEDIANTE qRT-PCR. (2012).
ANÁLISIS DEL PERFIL DE EXPRESIÓN GÉNICA DE Fusarium spp. FRENTE A COMPUESTOS ANTIFÚNGICOS MEDIANTE qRT-PCR
Thesis
Patiño A, Amado Y, M. C. Cepero de García, Chaves D, Tabima J, Motta A, Cardenas M, Bernal A, Restrepo S, Celis A. (2011)
Virulence Gene Expression in Malassezia spp from Individuals with Seborrheic Dermatitis
Journal of Investigative Dermatology (ISSN 0022-202X)
Article
González A, Sierra R, Cardenas M, Grajales A, Restrepo S, M. C. Cepero de García, Celis A. (2009)
Physiological and Molecular Characterization of Atypical Isolates of Malassezia furfur
Journal of Clinical Microbiology (ISSN 0095-1137)
Article
Rincon S, Celis A, Sopo L, Motta A, M. C. Cepero de García. (2005)
Malassezia yeast species isolated from patients with dermatologic lesions
Biomedica (ISSN 0120-4157)
Article
Celis A, M. C. Cepero de García. (2005)
Polimorfismos genéticos de aislamientos del género Malassezia obtenidos en Colombia de pacientes con lesión dermatológica y sin ella
Biomedica (ISSN 0120-4157)
Article
Degrees
PhD Science
Doctoral degree
Universiteit Utrecht
2017
Holanda
Magíster En Ciencias Biológicas. Área: Microbiología
Master degree
Universidad De Los Andes
2003
Colombia
Bacteriólogo Y Laboratorista Clínico
Bachelor degree
Universidad-Colegio Mayor De Cundinamarca
1997
Colombia
Projects
- 2019
- Characterization of lipid droplets in Malassezia spp: unraveling the role in the lipid metabolism
Duration: 36 months
PR.3.2018.5507
Interest in the study of lipid droplets in other organisms than humans is increasing. Our previous results revealed that LDs are present and can be detected in Malassezia spp. However, LD structure and dynamics seem very different from LDs detected in human cells, even their morphology is very different. The lipid dependence in Malassezia genus makes this organelle very attractive to study and to characterize. We aim to understand the physiological relevance of LDs and the dynamic behavior of LDs in lipid homeostasis and metabolism. In addition, their contribution to cellular membrane and organelle integrity, stress response, prevention of lipotoxicity, growth and survival will be investigated. The main goal of this proposal is to characterize LDs from Malassezia spp by in silico genomic analysis, in combination with lipidomics and proteomics. Additionally, we will evaluate LD morphology and dynamics using live-cell imaging (confocal microscopy) and detailing the ultrastructure with transmission electron microscopy (TEM). The detection of the surface proteins in LDs will be performed by tagging perilipin protein using Agrobacterium-mediated genetic transformation system by a binary T-DNA vector with the green fluorescent protein gene (gfp). This research will allow us to investigate LD from Malassezia spp. at the cellular and molecular level, which may become highly relevant to understand and make assessments to the physiological regulation of global lipid metabolism in this yeast. Additionally, lipidomic and proteomic data integration will be carried out in order to contextualize lipid metabolism based on LD using a previously reported metabolic model. This contextualization will allow us to understand the underpinnings behind metabolic flow distribution in the dynamic of LD lipid content to have a better understanding of the regulatory systems, underlying lipid functions and interactions in the context of cellular and physiology aspects in the yeast.